Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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ODM pillow for sleep brands Taiwan
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.High-performance graphene insole OEM China
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Insole ODM factory in Taiwan
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan anti-bacterial pillow ODM design
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Insole ODM factory in Indonesia
Johns Hopkins Medicine researchers have discovered that certain retinal photoreceptors employ two signaling pathways simultaneously for vision signal transmission, suggesting ancient evolutionary origins. This finding provides new insights into the complex functioning of the mammalian eye and marks a significant advancement in the field of neuroscience. Neuroscientists at Johns Hopkins have demonstrated that specialized cells can signal the presence of light simultaneously in two distinct ways Working with mammalian retinal cells, neuroscientists at Johns Hopkins Medicine have shown that, unlike most light-sensing cells (photoreceptors) in the retina, one special type uses two different pathways at the same time to transmit electrical “vision” signals to the brain. The work also reveals that such photoreceptors, according to the researchers, may have ancient origins on the evolutionary scale. This and other findings, recently published in PNAS, “shed scientific as well as literal light” on a decades-long mystery about how such cells work, the researchers say. The new research was co-led by King-Wai Yau, Ph.D., professor in the Department of Neuroscience at the Johns Hopkins University School of Medicine, and postdoctoral fellow Guang Li. King’s previous work led to advances in understanding how light-sensing cells in the mammalian eye transmit signals to the brain, findings that may eventually help scientists learn why people without sight can still sense light. In animals, including humans, photoreceptors (light-sensing cells) called rods and cones are located in the retina, a tissue layer at the back of the eye that responds to light. The rods and cones analyze visual signals that are transmitted via electrical signals to the brain, which interprets what is “seen.” Another type of photoreceptors in the retina, called intrinsically-photosensitive retinal ganglion cells (ipRGCs), use long protrusions (axons) that form the optic nerve to convey visual signals from rods and cones. The ipRGCs also perform other functions, such as setting the body’s light-driven circadian rhythms and distinguishing contrast and color. Dual Pathway Discovery It has been known that photoreceptors in animals detect light by using a signaling pathway named for the cell’s origin. Photoreceptors of “microvillous” origin, similar to those in the fruit fly eye, use the enzyme phospholipase C to signal light detection — whereas, photoreceptors of ciliary origin, such as those in our rods and cones, use a cyclic-nucleotide pathway. To signal light detection, most photoreceptors use either the microvillous or ciliary pathway, not both. However, in experiments to further understand how ipRGCs work, Yau’s team found that ipRGCs use both pathways at the same time. The researchers discovered this by exposing ipRGCs to brief pulses of bright light. In those conditions, the microvillous signaling pathway produces faster electrical responses and precedes, with some overlap, a slower response by the ciliary pathway. Yau’s team found that all six subtypes of ipRGCs use both microvillous and ciliary signaling mechanisms — although at different percentages — at the same time. The Johns Hopkins team also found that while most photoreceptors using the ciliary signaling pathway use a particular cyclic nucleotide, cGMP, as the signaling messenger, ipRGCs use another, cAMP, which is similar to jellyfish, an animal much older on the evolutionary scale. This suggests that ipRGCs may have an ancient origin. Reference: “Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs” by Guang Li, Lujing Chen, Zheng Jiang and King-Wai Yau, 18 December 2023, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2315282120 Other Johns Hopkins researchers who contributed to this study are Lujing Chen and Zheng Jiang. This study was funded by a grant from the National Institutes of Health (R01 EY014596) and a Beckman-Argyros Award in Vision Research.
Researchers discovered that Tetrahymena conducts respiration uniquely. Using cryo-electron microscopy, they revealed unknown proteins in its electron transport chain, showing gaps in biodiversity knowledge and the power of structural biology. Tetrahymena, a tiny single-celled organism, turns out to be hiding a surprising secret: it’s doing respiration – using oxygen to generate cellular energy – differently from other organisms such as plants, animals, or yeasts. The discovery, published today (March 31, 2022) in the journal Science, highlights the power of new techniques in structural biology and reveals gaps in our knowledge of a major branch of the tree of life. “We thought we knew about respiration from studying other organisms, but this shows us how much we still don’t know,” said Maria Maldonado, a postdoctoral researcher in the Department of Molecular and Cellular Biology at the University of California, Davis and co-first author on the paper. Tetrahymena is a genus of free-living, single-celled organisms usually found quietly swimming around ponds by beating their coat of tiny hairs, or cilia. Like us, they are eukaryotes, with their genetic material in a nucleus. They belong to a large and diverse group of organisms called the SAR supergroup. With a few exceptions, such as the malaria parasite Plasmodium, the SAR supergroup is little studied. “It’s a huge proportion of the biosphere, but we don’t think about them much,” Maldonado said. Like all other eukaryotes – and some bacteria – Tetrahymena consume oxygen to generate energy through respiration, said James Letts, assistant professor of molecular and cellular biology in the UC Davis College of Biological Sciences. Oxygen comes in at the end of the series of chemical reactions involved in respiration. Electrons are passed through a chain of proteins located in structures called cristae in the inner membrane of the mitochondrion. This drives the formation of water from oxygen and hydrogen atoms, pumping protons across the membrane, which in turn drives the formation of the ATP, a store of chemical energy for the cell. This electron transport chain is fundamental to oxygen-based respiration in humans and other eukaryotes. New Approaches in Structural Biology There were clues that there is something different about the electron transport chain in Tetrahymena, Letts said. In the 1970s and 80s, scientists discovered that its electron-carrying protein – cytochrome c – and oxygen-consuming enzyme at the end of the chain – terminal oxidase – function differently than those in plants and animals. Until now, it wasn’t clear exactly how or why these enzymes differed in Tetrahymena when they were conserved across other studied eukaryotes. Maldonado, Letts, and co-first author Long Zhou used new approaches in structural biology to uncover the Tetrahymena electron transport chain. These included a cryo-electron microscopy structural proteomics approach – working out the structures of large number of proteins in a mixed sample at the same time. Cryo-electron microscopy freezes samples to extremely low temperatures, creating images at almost atomic resolution. Instead of imaging a single, purified protein, the team worked with mixed samples isolated from mitochondrial membranes and then taught an algorithm to recognize related structures. In this way, they were able to scan through hundreds of thousands of protein images and identify the structures of 277 proteins in three large assemblies, representing the Tetrahymena electron transport chain at near atomic resolution. Some of these proteins have no matching gene in the known Tetrahymena genome database – showing that there must be gaps in the available reference genome. By revealing the gaps in our knowledge of a fairly common organism, the work shows our blind spots with respect to biodiversity, Letts said. It also shows the potential of these new methods in structural biology as a discovery tool, he said. Reference: “Structures of Tetrahymena’s respiratory chain reveal the diversity of eukaryotic core metabolism” by Long Zhou, María Maldonado, Abhilash Padavannil, Fei Guo and James A. Letts31 March 2022, Science. DOI: 10.1126/science.abn7747 Part of the work was conducted with cryo-electron microscopes at the BioEM core facility at the UC Davis College of Biological Sciences. Additional authors on the paper are Abhilash Padavannil and Fei Guo, both at UC Davis. Zhou is now at Zhejiang University School of Medicine, Hangzhou, China. The work was supported by the NIH.
Researchers were stunned to find that bacteria exposed to microplastics develop stronger defenses against antibiotics. This unexpected discovery suggests that plastic pollution isn’t just an environmental crisis—it could also be accelerating the global rise of drug-resistant infections. Credit: SciTechDaily.com Scientists were shocked to discover that microplastics don’t just pollute the environment, they may also be fueling the rise of drug-resistant bacteria. Boston University researchers found that bacteria exposed to plastic particles became stronger against antibiotics, raising serious public health concerns. The impact could be especially severe in refugee communities, where plastic waste accumulates and infections spread easily. As microplastics continue to infiltrate our water, food, and air, they may be silently empowering superbugs in ways we never expected. Microplastics: A Hidden Global Threat Microplastics—tiny fragments of plastic waste—are everywhere. They have entered food chains, accumulated in oceans, drifted through clouds, settled on mountaintops, and even made their way into human bodies at alarming rates. Scientists are working urgently to understand the hidden consequences of this widespread pollution. One surprising and troubling discovery: microplastics may be contributing to antibiotic resistance. Boston University’s Startling Discovery Researchers at Boston University found that bacteria exposed to microplastics became resistant to multiple antibiotics commonly used to treat infections. This raises particular concerns for people living in overcrowded, underserved areas, such as refugee settlements, where plastic waste accumulates and bacterial infections spread more easily. The study, published on March 11 in Applied and Environmental Microbiology, highlights a growing public health risk. “The fact that there are microplastics all around us, and even more so in impoverished places where sanitation may be limited, is a striking part of this observation,” says Muhammad Zaman, a Boston University College of Engineering professor of biomedical engineering who studies antimicrobial resistance and refugee and migrant health. “There is certainly a concern that this could present a higher risk in communities that are disadvantaged, and only underscores the need for more vigilance and a deeper insight into [microplastic and bacterial] interactions.” Why Microplastics Are a Breeding Ground for Superbugs It’s estimated that there are 4.95 million deaths associated with antimicrobial-resistant infections each year. Bacteria become resistant to antibiotics for many different reasons, including the misuse and overprescribing of medications, but a huge factor that fuels resistance is the microenvironment—the immediate surroundings of a microbe—where bacteria and viruses replicate. In the Zaman Laboratory at BU, researchers rigorously tested how a common bacteria, Escherichia coli (E. coli), reacted to being in a closed environment with microplastics. “The plastics provide a surface that the bacteria attach to and colonize,” says Neila Gross (ENG’27), a BU PhD candidate in materials science and engineering and lead author of the study. Once attached to any surface, bacteria create a biofilm—a sticky substance that acts like a shield, protecting the bacteria from invaders and keeping them affixed securely. Even though bacteria can grow biofilms on any surface, Gross observed that the microplastic supercharged the bacterial biofilms so much that when antibiotics were added to the mix, the medicine was unable to penetrate the shield. Why Are Microplastic Biofilms So Dangerous? “We found that the biofilms on microplastics, compared to other surfaces like glass, are much stronger and thicker, like a house with a ton of insulation,” Gross says. “It was staggering to see.” The rate of antibiotic resistance on the microplastic was so high compared to other materials, that she performed the experiments multiple times, testing different combinations of antibiotics and types of plastic material. Each time, the results remained consistent. “We’re demonstrating that the presence of plastics is doing a whole lot more than just providing a surface for the bacteria to stick—they are actually leading to the development of resistant organisms,” Zaman says. He directs BU’s Center on Forced Displacement, which has a mission to improve the lives of displaced people around the world. Past research has found that refugees, asylum seekers, and forcibly displaced populations are at an increased risk of contracting drug-resistant infections, due to living in overcrowded camps and having heightened barriers to receiving healthcare. The Human Cost: Refugees and Drug Resistance “Historically, people have associated antibiotic resistance with patient behavior, like not taking antibiotics as prescribed. But there is nothing a person has done to be forced to live in a particular environment, and the fact is they are at a higher exposure to resistant infections,” Zaman says. That’s why the environmental and social causes of drug-resistant superbugs cannot be ignored, he says. As of 2024, there were an estimated 122 million displaced people worldwide. According to Zaman, the prevalence of microplastics could be adding another element of risk to already underfunded, and understudied, health systems that serve refugees. Next Steps: Unraveling the Mystery of Plastic and Bacteria Gross and Zaman say that the next step in their research is to figure out if their findings in the lab translate to the outside world. They hope to begin studies with research partners overseas to watch refugee camps for microplastic-related antibiotic-resistant bacteria and viruses. They also aim to figure out the exact mechanisms that allow bacteria to hold such a strong grip on plastic. “Plastics are highly adaptable,” Gross says, and their molecular composition could help bacteria flourish—but it’s unclear how that happens. One theory, she says, is that plastics repel water and other liquids, which allow bacteria to easily attach themselves. But over time, the plastics start to take in moisture. That means it’s possible for microplastics to absorb antibiotics before they reach the target bacteria. They also found that even when the microplastics were removed from the equation, the bacteria they once housed kept the ability to form stronger biofilms. A Call to Action for Scientists and Engineers “Too often, these issues are viewed from a lens of politics or international relations or immigration, and all of those are important, but the story that is often missing is the basic science,” Zaman says. “We hope that this paper can get more scientists, engineers, and more researchers to think about these questions.” Explore Further: Microplastics Are Fueling the Rise of Deadly Superbugs Reference: “Effects of microplastic concentration, composition, and size on Escherichia coli biofilm-associated antimicrobial resistance” by Neila Gross, Johnathan Muhvich, Carly Ching, Bridget Gomez, Evan Horvath, Yanina Nahum and Muhammad H. Zaman, 11 March 2025, Applied and Environmental Microbiology. DOI: 10.1128/aem.02282-24 This work was supported by the National Science Foundation.
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