Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Taiwan insole ODM design and production
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Memory foam pillow OEM factory China
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.High-performance insole OEM Indonesia
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan graphene product OEM factory
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.One-stop OEM/ODM solution provider Taiwan
Figure 1: A photo showing 1,3-butadiene produced from bacteria. Credit: © 2021 Yokohama Rubber Microbes are engineered to convert sugar into a chemical found in tires. The future environmental footprint of the tire industry could be substantially shrunk thanks to a new ecofriendly way found by four RIKEN researchers that harnesses bacteria to make a chemical used in synthetic rubber. Each year, factories around the world churn out more than 12 million metric tons of the organic chemical 1,3-butadiene, which is used in tires, adhesives, sealants, and other plastic and rubber products. They produce it by an energy-intensive process that relies on petroleum, which contributes to climate change. Researchers from the RIKEN Center for Sustainable Resource Science have engineered microbes to convert sugar into a chemical found in synthetic rubber. Credit: © 2021 RIKEN Center for Sustainable Resource Science Scientists have tried for many years to create 1,3-butadiene from more environmentally friendly starting materials by using specially designed microbes. But no one had previously succeeded in transforming a simple sugar such as glucose into the chemical in one easy step. Now, by engineering bacteria to convert glucose into 1,3-butadiene, Yutaro Mori and his three co-workers, all at the RIKEN Center for Sustainable Resource Science, have devised a sustainable approach to rubber and plastic production. “We constructed a novel artificial metabolic pathway and produced 1,3-butadiene directly from a renewable source—glucose,” says Mori. The RIKEN team succeeded in this long-sought goal by focusing on two parts of the biomanufacturing process. They first engineered a bacterial enzyme that could convert a biological compound that can be developed from glucose into 1,3-butadiene (Figure 1). The researchers then modified a strain of the bacterium Escherichia coli to use this enzyme and produce the chemical. Since 1,3-butadiene is a gas at room temperature, it can be easily captured as the bacteria continue to divide and grow. The technique still has a little way to go before it is ready for industrial primetime. The RIKEN team managed to synthesize only about 2 grams of 1,3-butadiene per liter of microbial brew. Much larger amounts will be needed for the method to be cost competitive with petroleum-based production. But with some additional engineering and optimization, Mori believes his team will get there. They are now further tweaking the bacterium’s metabolic pathways and enhancing the enzyme’s efficiency. In collaboration with the companies Yokohama Rubber and Zeon Corporation, the RIKEN team is also scaling up the protocol to work with larger volumes of microbes. The researchers are also exploring ways of harnessing the power of microbes to produce other chemicals from renewable resources. “After doing additional research into enzyme engineering and metabolic engineering, I hope we will be able to make a substantial contribution to realizing a low-carbon society and a sustainable bioeconomy in the not-so-distant future,” says Mori. Reference: “Direct 1,3-butadiene biosynthesis in Escherichia coli via a tailored ferulic acid decarboxylase mutant” by Yutaro Mori, Shuhei Noda, Tomokazu Shirai and Akihiko Kondo, 13 April 2021, Nature Communications. DOI: 10.1038/s41467-021-22504-6
Fat droplets in the fat cell of a mouse: The membrane of the droplets was stained green, and the fat stored in them was stained red. Credit: Johanna Spandl / University of Bonn The Study Offers the First Precise Understanding of Crucial Remodeling Processes in Adipose Tissue Fat cells utilize fat molecules as a means of energy storage. These molecules are comprised of three fatty acids attached to a glycerol backbone, and are commonly referred to as triglycerides. It has been long believed that these molecules undergo constant change during storage, being regularly broken down and reconstructed – a process known as “triglyceride cycling.” But is this assumption true, and if so, what is the purpose of this process? “Until now, there has been no real answer to these questions,” explains Prof. Dr. Christoph Thiele of the LIMES Institute at the University of Bonn. “It’s true that there has been indirect evidence of this permanent reconstruction for the past 50 years. However, direct evidence of this has so far been lacking.” The problem: To prove that triglycerides are broken down, and fatty acids modified and reincorporated into new molecules, one would need to track their transformation as they travel through the body. Yet there are thousands of different forms of triglycerides in each cell. Keeping track of individual fatty acids is therefore extremely difficult. Label Makes Fatty Acids Unmistakable “However, we have developed a method that allows us to attach a special label to fatty acids, making them unmistakable,” says Thiele. His research group labeled various fatty acids in this way and added them in a nutrient medium to mouse fat cells. The mouse cells then incorporated the labeled molecules into triglycerides. “We were able to show that these triglycerides do not remain unchanged, but are continuously degraded and remodeled: Each fatty acid is split off about twice a day and reattached to another fat molecule,” the researcher explains. But why is that? After all, this conversion costs energy, which is released as waste heat – what does the cell get out of it? Until now, it was thought that the cell needed this process to balance energy storage and supply. Or perhaps it is simply a way for the body to generate heat. “Our results now point to a completely different explanation,” Thiele explains. “It’s possible that in the course of this process, the fats are converted to what the body needs.” Poorly utilizable fatty acids would consequently be refined into higher-quality variants and stored in this form until they are needed. Fatty acids consist largely of carbon atoms, which hang one behind the other like the carriages of a train. Their length can be very different: Some consist of only ten carbon atoms, others of 16 or even more. In their study, the researchers produced three different fatty acids and labeled them. One of them was eleven, the second 16, and the third 18 carbon atoms long. “These chain lengths are typically found in food as well,” Thiele explains. Short Fatty Acids Are Eliminated, Long Ones “Improved” Labeling allowed the researchers to track exactly what happens to the fatty acids of different lengths in the cell. This showed that the fatty acids consisting of eleven carbon atoms were initially incorporated into triglycerides. After a short time, however, they were split off again and channeled out of the cell. After two days, they were no longer detectable. “Such shorter fatty acids are poorly usable by cells and can even damage them,” says Thiele, who is also a member of the Cluster of Excellence ImmunoSensation2. “Therefore, they are disposed of quickly.” In contrast, the 16- and 18-atom fatty acids remained in the cell, although not in their original fat molecules. They were also gradually chemically modified, for example by additional carbon atoms being inserted. In the original fatty acids, the carbon atoms were moreover linked with single bonds – roughly like a human chain in which neighbors join hands. Over time, this sometimes developed into double bonds – as if revelers at a party were doing a conga. The fatty acids that are formed in this process are called unsaturated. They are better utilizable for the body. “Overall, in this way the cells produce fatty acids that are more beneficial to the organism than those that we had originally supplied with the nutrient solution,” Thiele emphasizes. In the long term, this results for instance in the formation of oleic acid, a component of high-quality olive oil, from palmitate, such as that contained in palm fat. However, the cell cannot change the fatty acids as long as they are inside the fat molecule. They must first be split off, then modified, and finally tacked back on. Thiele: “Without triglyceride cycling, there is also no fatty acid modification.” Adipose tissue can therefore improve triglycerides. If we eat and store food with unfavorable fatty acids, they do not have to be released in that state again when we are hungry. What we get back contains fewer “short” fatty acids, more oleic acid (instead of palmitate), and more of the important arachidonic acid (instead of linoleic acid). “Nevertheless, we should take care in our diet to consume high-quality dietary fats as much as possible,” the researcher stresses. Because the refinement never works 100 percent. In addition, some of the fatty acids are not stored but used directly in the body. In the next step, the researchers now want to test whether the same processes occur in human adipose tissue as in individual mouse fat cells in the test tube. They also want to find out which enzymes make cycling work. Reference: “Triglyceride cycling enables modification of stored fatty acids” by Klaus Wunderling, Jelena Zurkovic, Fabian Zink, Lars Kuerschner and Christoph Thiele, 3 April 2023, Nature Metabolism. DOI: 10.1038/s42255-023-00769-z The study was funded by the German Research Foundation (DFG).
In the two decades since the human genome sequence, its potential remains unfulfilled, ushering in a new era of genetic research with unanswered questions for the next generation of scientists. When President Bill Clinton took to a White House lectern 20 years ago to announce that the human genome sequence had been completed, he hailed the breakthrough as “the most important, most wondrous map ever produced by humankind.” The scientific achievement was placed on par with the moon landings. It was hoped that having access to the sequence would transform our understanding of human disease within 20 years, leading to better treatment, detection, and prevention. The famous journal article that shared our genetic ingredients with the world, published in February 2001, was welcomed as a “Book of Life” that could revolutionize medicine by showing which of our genes led to which illnesses. But in the two decades since, the sequence has underwhelmed. The potential of our newfound genetic self-knowledge has not been fulfilled. Instead, what has emerged is a new frontier in genetic research: new questions for a new batch of researchers to answer. Today, the gaps between our genes, and the switches that direct genetic activity, are emerging as powerful determinants behind how we look and how we get ill – perhaps deciding up to 90% of what makes us different from one another. Understanding this “genetic dark matter,” using the knowledge provided by the human genome sequence, will help us to push further into our species’ genetic secrets. The announcement was first made in a joint press conference between President Bill Clinton and Prime Minister Tony Blair in 2000. Unraveled code Cracking the human genetic code took 13 years, US$2.7 billion (£1.9 billion) and hundreds of scientists peering through over 3 billion base pairs in our DNA. Once mapped, our genetic data helped projects like the Cancer Dependency Map and the Genome Wide Association Studies better understand the diseases that afflict humans. But some results were disappointing. Back in 2000, as it was becoming clear the genome sequence was imminent, the genomics community began excitedly placing bets predicting how many genes the human genome would contain. Some bets were as high as 300,000, others as low as 40,000. For context, the onion genome contains 60,000 genes. Dispiritingly, it turned out that our genome contains roughly the same number of genes as a mouse or a fruit fly (around 21,000), and three times less than an onion. Few would argue that humans are three times less complex than an onion. Instead, this discovery suggested that the number of genes in our genome had little to do with our complexity or our difference from other species, as had been previously assumed. Great responsibility Access to the human genome sequence also presented the scientific community with a huge number of important ethical questions, underscored in 2000 by Prime Minister Tony Blair when he cautioned: “With the power of this discovery comes the responsibility to use it wisely.” Ethicists were particularly concerned about questions of “genetic discrimination,” like whether our genes could be used against us as evidence in a court of law, or as a basis for exclusion: a new kind of twisted hierarchy determined by our biology. Some of these concerns were addressed by legislation against genetic discrimination, like the US Genetic Information Nondiscrimination Act of 2008. Other concerns, like those around so-called “designer babies,” are still being put to the test today. In 2018, human embryos were gene edited by a Chinese scientist, using a method called CRISPR which allows targeted sections of DNA to be snipped off and replaced with others. The scientist involved was subsequently jailed, suggesting that there remains little appetite for human genetic experimentation. On the other hand, to deny available genetic treatments to willing patients may one day be considered unethical – just as some countries have chosen to legalize euthanasia on ethical grounds. Questions remain about how humanity should handle its genetic data. The Chinese scientist He Jiankui announced in 2018 that he had created gene-edited twins. He was jailed in 2019. Disease diversions With human gene editing still highly contentious, researchers have instead looked to find out which genes may be responsible for humanity’s illnesses. Yet when scientists investigated which genes are linked to human diseases, they were met with a surprise. After comparing huge samples of human DNA to find whether certain genes led to certain illnesses, they found that many unexpected sections of the genome were involved in the development of human disease. The genome contains two sections: the coding genome, and the non-coding genome. The coding genome represents just 1.7% of our DNA, but is responsible for coding the proteins that are the essential building blocks of life. Genes are defined by their ability to code proteins: so 1.7% of our genome consists of genes. The non-coding genome, which makes up the remaining 98.3% of our DNA, doesn’t code proteins. This largely unknown section of the genome was once dismissed as “junk DNA,” previously thought to be useless. It contained no protein-creating genes, so it was assumed the non-coding genome had little to do with the stuff of life. Bewilderingly, scientists found that the non-coding genome was actually responsible for the majority of information that impacted disease development in humans. Such findings have made it clear that the non-coding genome is actually far more important than previously thought. Enhanced capabilities Within this non-coding part of the genome, researchers have subsequently found short regions of DNA called enhancers: gene switches that turn genes on and off in different tissues at different times. They found that enhancers needed to shape the embryo have changed very little during evolution, suggesting that they represent a major and important source of genetic information. These studies inspired one of us, Alasdair, to explore the possible role of enhancers in behaviors such as alcohol intake, anxiety, and fat intake. By comparing the genomes of mice, birds, and humans we identified an enhancer that has changed relatively little over 350 million years – suggesting its importance in species’ survival. When we used CRISPR genome editing to delete this enhancer from the mouse genome, those mice ate less fat, drank less alcohol, and displayed reduced anxiety. While these may all sound like positive changes, it’s likely that these enhancers evolved in calorically poor environments full of predators and threats. At the time, eating high-calorie food sources such as fat and fermented fruit, and being hyper-vigilant of predators, would have been key for survival. However, in modern society these same behaviors may now contribute to obesity, alcohol abuse, and chronic anxiety. Intriguingly, subsequent genetic analysis of a major human population cohort has shown that changes in the same human enhancer were also associated with differences in alcohol intake and mood. These studies demonstrate that enhancers are not only important for normal physiology and health, but that changing them could result in changes in behavior that have major implications for human health. Given these new avenues of research, we appear to be at a crossroads in genetic biology. The importance of gene enhancers in health and disease sits uncomfortably with our relative inability to identify and understand them. And so in order to make the most of the sequencing of the human genome two decades ago, it’s clear that research must now look beyond the 1.7% of the genome that encodes proteins. In exploring uncharted genetic territory, like that represented by enhancers, biology may well locate the next swathe of healthcare breakthroughs. Written by: Alasdair Mackenzie, Reader, Molecular Genetics, University of Aberdeen Andreas Kolb, Senior Research Fellow, The Rowett Institute, University of Aberdeen Adapted from an article originally published on The Conversation.
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